The Human Genome Project, which began in 1990, aimed to sequence the human genome to the fullest extent possible. By 2003, project scientists had revealed a genome sequence that covered over 90% of the human genome, a significant achievement considering the technology available at the time.
However, a recent investigation by science journalist Ashley Smart has shed light on a dubious consent issue at the heart of the project. DNA samples were collected from anonymous volunteers who were under the impression that the final project would be a mosaic of DNA from multiple individuals. Surprisingly, it was discovered that over two-thirds of the DNA used in the project came from a single individual, known as RP11, without his knowledge.
The decision to make RP11 the major donor raises important ethical questions about consent and transparency in genetic research. Understanding this history is crucial in the field of genetics today, as it highlights the need for clear communication and ethical guidelines when collecting and using DNA samples for research purposes.
For more information on this investigation, you can read Ashley’s full article in Undark Magazine. If you have any biology-related stories you’d like us to cover, feel free to email us at shortwave@npr.org.
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Today’s episode was produced by Berly McCoy, edited by Rebecca Ramirez, and fact-checked by both. Kwesi Lee served as the audio engineer for this episode, ensuring that our listeners receive high-quality sound production for their listening experience.
